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Pepperoni vs. Salami — Health Impact and Nutrition Comparison

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Article author photo Jack  Yacoubian by Jack Yacoubian | Last updated on May 11, 2023
Medically reviewed by Arpi Gasparyan Article author photo Arpi Gasparyan
Pepperoni
vs
Salami

Summary

Pepperoni is cheaper and spicier when it comes to its taste. Pepperoni is higher in calories and fat content but richer in vitamins A, E, and D. Comparatively, salami is richer in proteins, most B complex vitamins, and minerals. They mostly have negative impacts on overall health.

Introduction

Pepperoni is an American-Italian creation. It is derived from salami in the United States. It is made with cured beef or pork meat with paprika, cayenne pepper, chili pepper, and other spices. It is most famous as a pizza topping and one of the essential toppings in American pizzerias. Pepperoni was first prepared in New York in 1919; it was done by Italians who had moved to the United States, mostly from the southern part of Italy, where salami was famous. Pepperoni is famous for foods like pizza, meat boards, pepperoni rolls with cheese, etc. It is the most common type of topping on pizza.

On the other hand, salami has originated in Italy since the Roman ages; however, many European countries have their type of salami because it can stay without refrigeration for up to 40 days, even when cut. Salami production has to undergo two steps which are fermentation and drying.

What is the actual difference?

There are differences between pepperoni and salami. These differences vary among its origin, price, preparation methods, shelf life, and taste, among other things.

Origin

Pepperoni was created in New York by Italians who moved there in 1919. Whereas salami was created in Italy in the Roman ages, many European countries have versions.

Price

Salami is more expensive than pepperoni.

Methods of preparation

The main difference between pepperoni and salami is that pepperoni is prepared by curing meat, either pork or beef. It has finer ground meat with spicier flavors compared to salami. Covering the whole pepperoni is an artificial casing. On the other hand, salami has to undergo two steps of preparation which are fermentation and drying. Salami has to be mixed with yeast and bacteria to start the fermentation process. In addition, salami is cased in a gut casing, which is natural.

Shelflife

Salami has a longer shelf life; even if cut, it can stay in a clean environment without refrigeration for 40 days. This is the main important usage of this meat in old civilizations where refrigerators didn't exist. A constant supply of meat that can stay up to 40 days without rotting.

Taste

Pepperoni is saltier and spicier than salami. Pepperoni is finer ground meat that is mostly softer than salami; however, both are soft cuts with a wide range of flavor profiles.

In this article, we will discuss the difference between pepperoni and salami according to their differences based on their nutritional content, diet and weight loss, and health impacts.

You can also read the comparison of pepperoni vs chorizo

Nutritional content comparison

Glycemic index

Both pepperoni and salami are low glycemic index foods.

Calories

Pepperoni is 1.5 times higher in calories compared to salami. This difference is very significant between them.

Pepperoni contains 504 calories in comparison to salami which contains 336 calories. 

Carbs

They are both low in carbs. Comparatively, salami contains more carbs than pepperoni.

Protein

Salami is richer in proteins than pepperoni. Pepperoni contains 19.25g of proteins, whereas salami contains 21.85g.

It is important to note that both are rich in protein and have complete essential amino acid profiles.

Fats

Fat contents in both foods are very high and must be considered during diets and everyday consumption of pepperoni or salami. Pepperoni contains almost double the amount of fat as salami. Nearly 46% of pepperoni's weight is fat.

Their fat profiles are mainly distributed among saturated fats and monounsaturated fats. The latter has a higher content in both.

Fat Type Comparison

Fat type breakdown side-by-side comparison
Contains more Monounsaturated Fat +86.7%
Contains more Polyunsaturated fat +76.3%
Contains less Saturated Fat -47.4%
41% 48% 10%
Saturated Fat: 17.708 g
Monounsaturated Fat: 20.77 g
Polyunsaturated fat: 4.458 g
41% 48% 11%
Saturated Fat: 9.316 g
Monounsaturated Fat: 11.127 g
Polyunsaturated fat: 2.529 g
Contains more Monounsaturated Fat +86.7%
Contains more Polyunsaturated fat +76.3%
Contains less Saturated Fat -47.4%

Cholesterol

Pepperoni is higher in cholesterol than salami. Pepperoni contains 97mg of cholesterol, while salami contains 89mg.

Vitamin profile

Comparatively, salami has a richer and more versatile vitamin profile than pepperoni. Salami is richer in vitamins B1, B2, B3, B5, B6, B12. On the other hand, pepperoni is richer in vitamins A, D, and E.

The vitamin B complex content of salami is very rich and satisfies high amounts of the recommended daily values of each of the B complex vitamins.

Vitamin Comparison

Vitamin comparison score is based on the number of vitamins by which one or the other food is richer. The "coverage" charts below show how much of the daily needs can be covered by 300 grams of the food.
:
6
Salami
Contains more Vitamin E +368.2%
Contains more Vitamin D +30%
Contains more Folate +66.7%
Contains more Vitamin K +81.3%
Contains more Vitamin B1 +35.4%
Contains more Vitamin B2 +38.9%
Contains more Vitamin B3 +21.4%
Contains more Vitamin B5 +29.1%
Contains more Vitamin B6 +26.8%
Contains more Vitamin B12 +16.9%
Vitamin A Vitamin E Vitamin D Vitamin C Vitamin B1 Vitamin B2 Vitamin B3 Vitamin B5 Vitamin B6 Folate Vitamin B12 Vitamin K 0% 21% 39% 0% 68% 60% 94% 56% 84% 4% 163% 15%
Vitamin A Vitamin E Vitamin D Vitamin C Vitamin B1 Vitamin B2 Vitamin B3 Vitamin B5 Vitamin B6 Folate Vitamin B12 Vitamin K 0% 5% 30% 0% 92% 83% 114% 73% 106% 3% 191% 8%
Contains more Vitamin E +368.2%
Contains more Vitamin D +30%
Contains more Folate +66.7%
Contains more Vitamin K +81.3%
Contains more Vitamin B1 +35.4%
Contains more Vitamin B2 +38.9%
Contains more Vitamin B3 +21.4%
Contains more Vitamin B5 +29.1%
Contains more Vitamin B6 +26.8%
Contains more Vitamin B12 +16.9%

Mineral profile

Salami is richer in all minerals. Salami is richer in phosphorus, zinc, copper, and iron. In addition, salami has a higher content of sodium which is a matter of concern. Noting that pepperoni is also high in sodium.

Both are very high in sodium. Pepperoni and salami contain 1582mg and 1740mg of sodium per 100g serving, respectively. Pepperoni covers up to 70% of the recommended daily sodium intake.

In the diagram below, we can visualize their distribution. 

Mineral Comparison

Mineral comparison score is based on the number of minerals by which one or the other food is richer. The "coverage" charts below show how much of the daily needs can be covered by 300 grams of the food.
Contains more Calcium +26.7%
Contains more Iron +17.3%
Contains more Phosphorus +20.9%
Contains more Potassium +15.3%
Contains more Zinc +20.1%
Contains more Copper +292.3%
Equal in Magnesium - 19
Equal in Sodium - 1740
Equal in Manganese - 0.978
Equal in Selenium - 31.3
Calcium Iron Magnesium Phosphorus Potassium Sodium Zinc Copper Manganese Selenium 6% 50% 13% 68% 25% 207% 67% 31% 141% 159%
Calcium Iron Magnesium Phosphorus Potassium Sodium Zinc Copper Manganese Selenium 5% 59% 14% 82% 28% 227% 80% 119% 128% 171%
Contains more Calcium +26.7%
Contains more Iron +17.3%
Contains more Phosphorus +20.9%
Contains more Potassium +15.3%
Contains more Zinc +20.1%
Contains more Copper +292.3%
Equal in Magnesium - 19
Equal in Sodium - 1740
Equal in Manganese - 0.978
Equal in Selenium - 31.3

Diet and weight loss

Pepperoni and salami are not recommended to be eaten on weight-loss regimens. This is mostly owing to their high fat and salt content. Despite being high in protein, they have a high-fat content. Furthermore, the salt levels, particularly in salami, are very high.

Vegan

Pepperoni and salami are excluded from the vegan diet. However, some vegan alternatives for both are available. Each vegan version is usually made out of wheat gluten and other spices.

Keto

On a keto diet, you can consume pepperoni and salami. They have low carbohydrate and glycemic index, and their macronutrient makeup comprises protein and lipids. However, it is vital to note that the salt level of these foods should be considered when consuming them.

Health impacts

Cardiovascular health and diabetes

Processed meat, like red meat, is a risk factor for metabolic syndrome. It is vital to note that processed meat, such as pepperoni and salami, has a negative impact on cardiovascular health and metabolism. 

Consuming processed meat has been linked to poor cardiovascular health outcomes and an increased risk of acquiring type 2 diabetes. Fats, cholesterol, increased sodium, and nitrites are the primary contributors to these issues.

Nitrite levels in pepperoni and salami are a major risk factor for metabolic diseases. Nitrites and their metabolites have been linked to type 1 diabetes, endothelial dysfunction, insulin resistance, and type 2 diabetes. In most cases, nitrites are used as preservatives in processed meats (1, 2, 3, 4, 5, 6).

Cancer

Nitrates and nitrites in processed meat have a role in inhibiting bacterial growth, increasing the shelf life of these products. However, nitrates are transformed into nitrites due to the effect of anaerobic bacteria. Nitrites have a carcinogenic characteristic that must be considered while consuming processed meat. The meat industry is trying to find alternatives for nitrites and nitrates; however, finding an alternative is challenging due to their multi-role usage (7).

Digestion

Both pepperoni and salami may trigger heartburn.

People with acid reflux, GERD, peptic ulcer disease, IBS, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), and pancreatitis should avoid both pepperoni and salami, as they may worsen the symptoms (8, 9, 10).

People with gastroparesis may also benefit from avoiding these foods.

Alternatives

Vegan pepperoni has different products used to make pepperoni, like tofu, vital wheat gluten, legumes, etc. The fat, cholesterol, and sodium level are drastically decreased and provide a healthy alternative to pepperoni. However, taste and flavor must be compromised in this case.

On the other hand, there are vegan alternatives to salami, mainly made with vital wheat gluten. Like pepperoni, fat, cholesterol, and sodium levels are decreased.

Both vegan alternatives provide healthier alternatives to the standard pepperoni and salami. Their nutritional content would be decreased from most negative health impacts like fat, sodium, and cholesterol. However, their protein content would also be reduced. In addition to that difference, the taste and flavor would be changed; however, vegan pepperoni and salami producers are catering to those qualities to match the standard pepperoni and salami as much as they can.

Article author photo Jack  Yacoubian
Education: Haigazian Medical University
Last updated: May 11, 2023
Medically reviewed by Arpi Gasparyan

Infographic

Pepperoni vs Salami infographic
Infographic link

Macronutrient Comparison

Macronutrient breakdown side-by-side comparison
Contains more Fats +78.7%
Contains more Protein +13.5%
Contains more Carbs +103.4%
Contains more Water +58.3%
Equal in Other - 4.66
19% 46% 29% 5%
Protein: 19.25 g
Fats: 46.28 g
Carbs: 1.18 g
Water: 28.55 g
Other: 4.74 g
22% 26% 2% 45% 5%
Protein: 21.85 g
Fats: 25.9 g
Carbs: 2.4 g
Water: 45.19 g
Other: 4.66 g
Contains more Fats +78.7%
Contains more Protein +13.5%
Contains more Carbs +103.4%
Contains more Water +58.3%
Equal in Other - 4.66

Comparison summary table

Pay attention to the rightmost column. It displays the amounts side by side, giving a clearer understanding of the difference.
Pepperoni Salami
Lower in Cholesterol ok
Lower in Saturated Fat ok
Lower in price ok
Rich in minerals ok
Lower in Sugar ok
Lower in Sodium ok
Lower in Glycemic Index Equal
Rich in vitamins Equal

All nutrients comparison - raw data values

Nutrient Pepperoni Salami Opinion
Net carbs 1.18g 2.4g Salami
Protein 19.25g 21.85g Salami
Fats 46.28g 25.9g Pepperoni
Carbs 1.18g 2.4g Salami
Calories 504kcal 336kcal Pepperoni
Sugar 0g 0.96g Pepperoni
Calcium 19mg 15mg Pepperoni
Iron 1.33mg 1.56mg Salami
Magnesium 18mg 19mg Salami
Phosphorus 158mg 191mg Salami
Potassium 274mg 316mg Salami
Sodium 1582mg 1740mg Pepperoni
Zinc 2.44mg 2.93mg Salami
Copper 0.091mg 0.357mg Salami
Manganese 1.074mg 0.978mg Pepperoni
Selenium 29µg 31.3µg Salami
Vitamin E 1.03mg 0.22mg Pepperoni
Vitamin D 52IU 41IU Pepperoni
Vitamin D 1.3µg 1µg Pepperoni
Vitamin B1 0.271mg 0.367mg Salami
Vitamin B2 0.257mg 0.357mg Salami
Vitamin B3 4.987mg 6.053mg Salami
Vitamin B5 0.93mg 1.201mg Salami
Vitamin B6 0.362mg 0.459mg Salami
Folate 5µg 3µg Pepperoni
Vitamin B12 1.3µg 1.52µg Salami
Vitamin K 5.8µg 3.2µg Pepperoni
Tryptophan 0.23mg 0.114mg Pepperoni
Threonine 0.869mg 0.521mg Pepperoni
Isoleucine 0.901mg 0.675mg Pepperoni
Leucine 1.575mg 0.929mg Pepperoni
Lysine 1.652mg 1.107mg Pepperoni
Methionine 0.511mg 0.301mg Pepperoni
Phenylalanine 0.778mg 0.481mg Pepperoni
Valine 0.987mg 0.668mg Pepperoni
Histidine 0.688mg 0.359mg Pepperoni
Cholesterol 97mg 89mg Salami
Trans Fat 1.527g 0.586g Salami
Saturated Fat 17.708g 9.316g Salami
Omega-3 - DHA 0.004g 0g Pepperoni
Omega-3 - EPA 0.004g 0g Pepperoni
Omega-3 - DPA 0.02g 0g Pepperoni
Monounsaturated Fat 20.77g 11.127g Pepperoni
Polyunsaturated fat 4.458g 2.529g Pepperoni
Omega-6 - Eicosadienoic acid 0.136g 0.084g Pepperoni
Omega-6 - Linoleic acid 3.605g 2.104g Pepperoni
Omega-6 - Gamma-linoleic acid 0.002g 0g Pepperoni
Omega-3 - ALA 0.164g 0.126g Pepperoni
Omega-3 - Eicosatrienoic acid 0.018g Pepperoni
Omega-6 - Dihomo-gamma-linoleic acid 0.04g Pepperoni

Which food is preferable for your diet?

ok
ok
is better in case of low diet
Pepperoni Salami
Low Fats diet ok
Low Carbs diet ok
Low Calories diet ok
Low Glycemic Index diet Equal

People also compare

Vitamins & Minerals Daily Need Coverage Score

The summary scores indicate the extent to which this food can fulfill your daily vitamin and mineral requirements if you consume 3 servings, consisting of 100 grams of each (an approximation of 3 serving sizes).
Vitamins Daily Need Coverage Score
50%
Pepperoni
58%
Salami
Minerals Daily Need Coverage Score
76%
Pepperoni
91%
Salami

Comparison summary

Which food is lower in Cholesterol?
Salami
Salami is lower in Cholesterol (difference - 8mg)
Which food is lower in Saturated Fat?
Salami
Salami is lower in Saturated Fat (difference - 8.392g)
Which food is cheaper?
Salami
Salami is cheaper (difference - $0.3)
Which food is richer in minerals?
Salami
Salami is relatively richer in minerals
Which food is lower in Sugar?
Pepperoni
Pepperoni is lower in Sugar (difference - 0.96g)
Which food contains less Sodium?
Pepperoni
Pepperoni contains less Sodium (difference - 158mg)
Which food is lower in glycemic index?
?
The foods have equal glycemic indexes (28)
Which food is richer in vitamins?
?
It cannot be stated which food is richer in vitamins. See the charts below for detailed information. See the charts below for detailed information. See the charts below for detailed information.

References

All the values for which the sources are not specified explicitly are taken from FDA’s Food Central. The exact link to the food presented on this page can be found below.

  1. Pepperoni - https://fdc.nal.usda.gov/fdc-app.html#/food-details/174575/nutrients
  2. Salami - https://fdc.nal.usda.gov/fdc-app.html#/food-details/172936/nutrients

All the Daily Values are presented for males aged 31-50, for 2000-calorie diets.

Data provided by FoodStruct.com should be considered and used as information only. Please consult your physician before beginning any diet.